Human Sera
Cayman Chemical ElvItegravIr 50mg
A quinolone antibiotic that inhibits HIV-1 integrase (IC50 = 7.2 nM); has antiviral activity against laboratory strains and clinical isolates of HIV-1 in MAGI cells (EC50s = 0.1-1.26 nM) and HIV-2 in PBMCs (EC50s = 0.3-0.9)
Cayman Chemical Ciclesonide 50MG
A prodrug form of desisobutyryl-ciclesonide; binds to the glucocorticoid receptor (Ki = 37 nM); selective for the glucocorticoid receptor over the estrogen, progesterone, and testosterone receptors; inhibits eosinophil influx into the lung (ED50 = 0.49 mg/kg) and reduces sephadex-induced lung edema (ED50 = 0.72 mg/kg) in a rat model of ovalbumin-sensitized and -challenged airway inflammation
Cayman Chemical Velpatsvr 50mg
An NS5A inhibitor; inhibits replication of HCV genotypes 1-6 (EC50s = 6-130 pM in replicon assays); inhibits SARS-CoV-2 exonuclease activity at 100 µM; enhances remdesivir-induced inhibition of SARS-CoV-2 replication in infected Calu-3 cells at 10 µM
Cayman Chemical NicoinamID MononucleoID 100mg
An intermediate in the biosynthesis of NAD+ that has been used to enhance NAD biosynthesis and glucose-stimulated insulin secretion in Nampt+/- mice and high-fat diet-induced type 2 diabetes mice
Cayman Chemical NicotinamID MononucleotID 50mg
An intermediate in the biosynthesis of NAD+ that has been used to enhance NAD biosynthesis and glucose-stimulated insulin secretion in Nampt+/- mice and high-fat diet-induced type 2 diabetes mice
Cayman Chemical 1PalmItoyl2Oleoylsnglyce 100mg
Phospholipids used for liposome production in order to study the properties of lipid bilayers
Cayman Chemical NorepInphrInbItartrat 100mg
A natural neurotransmitter and hormone that acts as an agonist of adrenergic receptors (Ki values are 330, 56, and 740 nM for α1, α2, and β1 adrenoceptors, respectively)
Cayman Chemical DoxorubIcInhydrochlorIde 50mg
An anthracycline antitumor antibiotic agent that inhibits DNA topoisomerase II by inducing double-stranded DNA breaks; inhibits nucleic acid synthesis and induces apoptosis by intercalating within DNA
Cayman Chemical 1Stearoyl2hydroxysnglyce 100mg
A phosphatidylcholine; increases IL-1β production in isolated human blood monocytes at 12.5 µM; plasma levels are decreased in patients with lung cancer
Cayman Chemical ZalcItabIn 100mg
A NRTI; reduces the replication of laboratory-adapted and clinical isolates of HIV in a plaque reduction assay (IC50s = 0.013-0.08 µM)
Cayman Chemical LIpId HTO12 50mg
An ionizable cationic lipid (pKa = 6.432); has been used in combination with other lipids in the formation of LNPs for the delivery of mRNA in vitro and in vivo; LNPs containing lipid HTO12 and encapsulating adenine base editor mRNA targeting Pcsk9 reduce hepatic Pcsk9 levels in mice at a reduced ionizable lipid/total lipids-to-mRNA ratio than LNPs containing SM-102
Cayman Chemical TolbutamIde 100mg
A SUR1/Kir6.2 channel inhibitor (IC50 = 4.9 µM); selective for SUR1/Kir6.2 over SUR2A/Kir6.2 and SUR2B/Kir6.2 channels (IC50s = 85 and 88 µM, respectively); increases glucose-induced insulin secretion and calcium influx in isolated mouse pancreatic islets; reduces blood glucose levels in a mouse model of STZ-induced diabetes at 80 mg/kg
Cayman Chemical GlycoursodeoxycholIc ACD 100mg
A glycine-conjugated form of ursodeoxycholic acid; has antioxidant effects in vitro in Barrett’s esophagus cells and primary cultured rat neurons; reduces the levels of inflammatory cytokines and prevents cell death induced by unconjugated bilirubin in an astroglial cell model of neonatal hyperbilirubinemia; decreases the severity of symptoms and increases the amount of A. muciniphila in a mouse model of colitis at 500 mg/kg per day
Cayman Chemical BrasInolIde 50mg
A biologically active brassinosteroid that has important roles in regulating plant growth and development