Human Sera
Cayman Chemical 4-Methylumbelliferyl Oleate, Purity: ≥98%, CAS: 18323-58-5, 50 mg
A fluorogenic substrate for acid and alkaline lipases
Cayman Chemical Gardiquimod, Purity: ≥95%, CAS: 1020412-43-4, 50 mg
A selective agonist of human TLR7; enhances the immunosuppressive activity of Treg cells at 0.5 to 2 µg/ml
Cayman Chemical Brassinazole, Purity: ≥98%, CAS: 224047-41-0, 50 mg
An inhibitor of brassinosteroid biosynthesis that at 1 µM can induce morphological changes, including dwarfism and altered leaf color and curling, in dark-grown Arabidopsis and light-grown cress
Cayman Chemical Sinomenine (hydrochloride), Purity: ≥98%, CAS: 6080-33-7, 50 mg
A natural plant alkaloid commonly used to alleviate inflammation associated with rheumatoid arthritis; activates histamine release, reduces joint stiffness and pain, and alters cytokine generation; impairs signaling through NF-κB, resulting in immunosuppression as well as reduced inflammation and pain
Cayman Chemical Fluvoxamine (maleate), Purity: ≥95%, CAS: 61718-82-9, 50 mg
An SSRI; selectively inhibits reuptake of serotonin over norepinephrine reuptake in rat hypothalamic synaptosomes (Kis = 6.2 and 1,100 nM, respectively); reduces immobility time in the forced swim test in mice at 10 mg/kg, an effect that can be blocked by a σ1 receptor antagonist; reduces marble-burying behavior in the marble-burying test in mice at 45 mg/kg
Cayman Chemical XTT (sodium salt hydrate), Purity: ≥98%, CAS: 413585-64-5, 100 mg
A cell-impermeable, negatively charged tetrazolium dye that produces a water-soluble formazan when reduced at the cell surface by cellular-derived NADH and an electron mediator
Cayman Chemical Pranoprofen, Purity: ≥98%, CAS: 52549-17-4, 50 mg
An NSAID and COX-1 inhibitor (IC50 = 3.1 µM); decreases B. pertussis-induced PGE2 production in isolated rat peritoneal leukocytes (IC50 = 0.39 µM); reduces corneal epithelial damage in a mouse model of corneal alkali burns when applied ocularly
Cayman Chemical Fenoldopam (mesylate), Purity: ≥95%, CAS: 67227-57-0, 50 mg
An agonist of dopamine D1A (D1R) and D1B (D5R) receptors (Kds = 17 and 11 nM, respectively); alters hemodynamic properties, including hypertension, in animals.
Cayman Chemical Elvitegravir, Purity: ≥98%, CAS: 697761-98-1, 100 mg
A quinolone antibiotic that inhibits HIV-1 integrase (IC50 = 7.2 nM); has antiviral activity against laboratory strains and clinical isolates of HIV-1 in MAGI cells (EC50s = 0.1-1.26 nM) and HIV-2 in PBMCs (EC50s = 0.3-0.9)
Cayman Chemical SB-258585 (hydrochloride), Purity: ≥95%, 50 mg
A potent, selective antagonist of the serotonin 5-HT6 receptor (pKi = 8.53); has been used in cells and in animals
Cayman Chemical Temocapril (hydrochloride), Purity: ≥98%, CAS: 110221-44-8, 50 mg
A prodrug form of temocaprilat; prevents impairment of acetylcholine-induced relaxation in aortic rings isolated from diabetic rats in a model of streptozotocin-induced diabetes; inhibits the angiotensin I-induced pressor response in normotensive rats at 0.1, 0.3, and 1 mg/kg; prevents coronary vascular remodeling induced by L-NAME in rats at 0.1 mg/ml in the drinking water; reduces plasma glucose levels in a KKAy mouse model of type 2 diabetes at 1 mg/kg
Cayman Chemical Monobromobimane, Purity: ≥98%, CAS: 71418-44-5, 50 mg
A thiol-reactive fluorogenic probe; used to evaluate or quantify a variety of compounds containing reactive sulfur or thiol groups, including H2S, glutathione, proteins, and nucleotides
Cayman Chemical Glufosinate (ammonium salt), Purity: ≥95%, CAS: 77182-82-2, 100 mg
A broad-spectrum herbicide; an irreversible inhibitor of GS1 and GS2 (Kis = 1.1. and 4.8 µM, respectively); reduces dry biomass of the weeds E. canadensis and L. rigidum (ED50s = 26 and 763 g/hectare, respectively); has no observed adverse effects in rats and mice at 4.1 and 17 mg/kg per day for three months
Cayman Chemical Cefamandole (sodium salt), Purity: ≥90%, CAS: 30034-03-8, 100 mg
A cephalosporin antibiotic that is effective against E. coli (MIC values range from 0.25-2 mg/L depending on strain) as well as H. influenza and S. aureus
Cayman Chemical (±)-trans-1,2-Bis(2-mercaptoacetamido)cyclohexane, Purity: ≥98%, CAS: 257641-01-3, 100 mg
A dithiol used, both in vitro and in vivo, to promote the correct folding of proteins that require disulfide bonds for functionality